Glycosylation of human receptor guanylyl cyclase C
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چکیده
منابع مشابه
Glycosylation of human receptor guanylyl cyclase C
Background Post translational modifications regulate several signalling pathways and glycosylation is emerging as a key player in this regulatory process. Glycosylation of cell surface receptors modulate the downstream signalling pathway and when altered causes a change in the normal physiology of the cell [1]. Guanylyl cyclase C (GC-C) belongs to a group of membrane bound receptors that produc...
متن کاملThe linker region in receptor guanylyl cyclases is a key regulatory module: mutational analysis of guanylyl cyclase C.
Receptor guanylyl cyclases are multidomain proteins, and ligand binding to the extracellular domain increases the levels of intracellular cGMP. The intracellular domain of these receptors is composed of a kinase homology domain (KHD), a linker of approximately 70 amino acids, followed by the C-terminal guanylyl cyclase domain. Mechanisms by which these receptors are allosterically regulated by ...
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Of the four endogenous members of the natriuretic peptide family, only atrial natriuretic peptide has been demonstrated to have neuromodulatory effects. This study compares the neuromodulatory effects of atrial natriuretic peptide and a recently identified natriuretic peptide, C-type natriuretic peptide, in the rabbit isolated vas deferens. The ability of these peptides to alter cyclic nucleoti...
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Introduction: Following a proximal small bowel resection (SBR), the intestine adapts by increased crypt depth and villus height compared to sham operated mice (transection and reanastomosis only). The epidermal growth factor receptor (EGFR) is a known mediator of intestinal adaptation and results in activation of the GTPase Rac. This activates PAK (p21-activated protein kinase) which may activa...
متن کاملPharmacological characterization of receptor guanylyl cyclase reporter cell lines
Receptor guanylyl cyclases are implicated in a growing number of pathophysiologies and, therefore, represent an important target class for drug development. We report here the generation and pharmacological characterization of three particulate guanylyl cyclase (pGC) reporter cell lines. Plasmid constructs encoding the natriuretic peptide receptors GC-A and GC-B, and the heat-stable enterotoxin...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2009
ISSN: 1471-2210
DOI: 10.1186/1471-2210-9-s1-p1